The presence of an arylate bond in a polymer backbone was found to introduce a hydrolytically labile linkage into the polymer structure. Under physiological conditions in vitro all polymers degraded; the films retained only about 30-40% of their initial molecular weight after 26 weeks of storage in phosphate buffer solutions.
Release studies with nitroaniline as a model drug indicated that a diffusion controlled release process occurred. The rate of nitroaniline release could be correlated with the glass transition temperature of the polymer.
Five structurally related, aliphatic polyarylates were synthesized from tyrosine-derived diphenols and diacids. The …
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